The College is owned and managed by the Diocese of Calicut. The Calicut diocese was founded on June 12; 1923.The Jesuit Missionaries who are pioneers in modern education gave the real footing for the educational requirement of the people of the Malabar area. The diocese of Calicut took to their heart this educational vision of the Jesuit missionaries and made substantial contribution in the educational scenario of the Malabar region. The contribution to the field of education had its impact in the socio cultural milieu of the region irrespective of caste and religion The educational commitment was basically focused on the empowerment and up-liftment of the people of the region.

Now realizing the signs of the time, the diocese felt the need for entering in to the field of higher education. Keeping this view in mind Rt. Rev. Dr. Joseph Kalathiparambil initiated the formation of the Educational and Charitable Trust of the Diocese of Calicut. St. Xavier’s Arts and Science College is the first brain child of the Trust. Very Rev. Msgr. Vincent Arackal, the administrator of the diocese is committed to carry out the vision of the Trust. He is the Manager of the College.

The College, with the name St. Xavier’s Arts and Science College was sanctioned by the Kerala Govt. on 01-09-11 and got affiliation from the University of Calicut on 20-09- 11 .The Inauguration of the College was held on 25-09-11 during which Mr. Pradeep Kumar M L A inaugurated the College. The College started functioning with its first batch of BCA a students on 28-09-11 in Navjyothis building at Eranhipalam. Rev. Dr. Joseph Mathew S J was appointed as its first Principal of the College. Fr. Johnson Averave assumed office as the Treasurer of the College. Rt. Rev. Dr. Joseph Kalathiparambil laid the foundation stone for the new College building on 19/05/12.

Rt. Rev. Dr. Varghese Chakkalakal assumed office as the 6th Bishop of the Diocese of Calicut on 10th June 2012. He is the Patron of the College. The academic year for the year 2012-13 was inaugurated by H. E. Rt.Rev. Dr.Varghese Chakkalackal on 28.06.12. He inaugurated the academic year for the year 2013-14 on 08.07.2013.The academic year for the year for the year 2014-15 was inaugurated by Adv. Niyas, Syndicate member on 18th Aug 2014 in the presence of the patron. Calicut Municipal corporation gave approval for the construction of the new building in 2015 February. The construction work of the new building started in the month of April 2015.The newly sanctioned M .Com programme was inaugurated on 30th Aug by Prof. M K Baby H O D of the Commerce dept at Devagiri College Calicut. Msgr (Dr) Thomas Panakkal and Fr. Paul Persy D’ Silva assumed office as the Manager and Procurator of the College respectively during the academic year. During the academic year 2015-16 Kerala government has sanctioned M A literature, B B A and B Sc Mathematics for the College.